Chemistry 128: Introduction to Chemical Biology
Chemistry 128: Introduction to Chemical Biology (Winter 2013, UC Irvine). Instructor: Professor Gregory Alan Weiss. Chemistry 128 provides an introduction to the basic principles of chemical biology: structures and reactivity; chemical mechanisms of enzyme catalysis; chemistry of signaling, biosynthesis, and metabolic pathways.
| Lecture 14 - Glycobiology |
| Time | Lecture Chapters |
| [00:02:04] | 1. Enzyme Functions |
| [00:06:10] | 2. Serine Based Proteases |
| [00:10:44] | 3. Protein Based Inhibition of Proteases |
| [00:13:10] | 4. Covalent or Mechanism-Based Protease Inhibitors |
| [00:15:02] | 5. Inhibition of Serine Esterases |
| [00:17:07] | 6. Enzymes Use Co-Factors (Vitamins) |
| [00:21:31] | 7. The Origins of Stereospecificity in Alcohol Dehydrogenase |
| [00:24:09] | 8. Pyridoxal Phosphate (Vitamin B6) |
| [00:27:29] | 9. PLP - Catalyzed Transamination |
| [00:29:29] | 10. Protein Engineering |
| [00:36:16] | 11. Most Mutations Make the Protein Less Functional |
| [00:38:17] | 12. Carbohydrates |
| [00:44:30] | 13. Hemiacetal Reactivity and Formation |
| [00:46:33] | 14. Glucopyranose is the Most Noteable Ring Configuration |
| [00:47:51] | 15. Oligosaccharides of the TB Coat |
| [00:51:29] | 16. Oxocarbenium Ions as a Key Intermediate in Hydrolysis of Glycosidic Bonds |
| [00:53:19] | 17. Mechanisms of Enzymatic Hydrolysis |
| [00:54:58] | 18. Commonalities in Glycosyl Hydrolase Mechanisms |
| [00:56:03] | 19. Neuraminidase: Key Enzyme in Influenza Release from Surface to Cell |
| [01:01:06] | 20. Oligosaccharides |
| [01:04:22] | 21. Polysaccharides |
| [01:08:04] | 22. Hyaluronan: Oligosaccharides in Joints |
| [01:09:57] | 23. Glycosylated Proteins |
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