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Chemistry 128: Introduction to Chemical Biology

Chemistry 128: Introduction to Chemical Biology (Winter 2013, UC Irvine). Instructor: Professor Gregory Alan Weiss. Chemistry 128 provides an introduction to the basic principles of chemical biology: structures and reactivity; chemical mechanisms of enzyme catalysis; chemistry of signaling, biosynthesis, and metabolic pathways.

Lecture 13 - Protein Function and Enzymes

Time Lecture Chapters
[00:00:00] 1. Enzymes
[00:03:20] 2. Repeat Proteins
[00:05:16] 3. Equilibrium Constants
[00:06:25] 4. Enzymatic Catalysts = Catalytic Receptors
[00:07:03] 5. Michaelis Constant for Measuring Catalysis
[00:15:30] 6. The Perfect Enzyme
[00:21:29] 7. Kinases: Phosphorylation of Ser/Thr or Tyr
[00:34:19] 8. Why Study Single Molecules?
[00:37:44] 9. How to Follow Enzymatic Catalysis with Single Walled Carbon Nanotubes
[00:41:34] 10. Single Biomolecule Bioelectronics
[00:44:24] 11. Before and After Enzyme Attachment
[00:46:29] 12. Watching cAMP - Dependent Protein Kinase A
[00:49:18] 13. Further Generalization: Protein A Kinase
[00:55:55] 14. Lysozyme as a Model Enzyme for Glycoside Hydrolysis
[01:08:22] 15. Proteases Cleave Amide Bonds
[01:12:37] 16. Regulation of Proteases Through Pro-Enzymes

Go to the Course Home or watch other lectures:

Lecture 01 - Introduction/What is Chemical Biology?
Lecture 02 - Common Tools in Chemical Biology
Lecture 03 - Reactivity and Arrow Pushing
Lecture 04 - Combinatorial Chemistry and Biology
Lecture 05 - Non-Covalent Interactions, DNA
Lecture 06 - DNA Reactivity with Small Molecules
Lecture 07 - DNA, RNA, and Cancer
Lecture 08 - RNA
Lecture 09 - RNA part 2
Lecture 10 - Proteins and Amino Acid Conformations
Lecture 11 - Proteins and Amino Acid Conformations, Part 2
Lecture 12 - Protein Functions
Lecture 13 - Protein Function and Enzymes
Lecture 14 - Glycobiology
Lecture 15 - Glycobiology and Polyketides
Lecture 16 - Glycobiology and Polyketides, Part 2
Lecture 17 - Terpenes and Cell Signaling, Part 1
Lecture 18 - Terpenes and Cell Signaling, Part 2