CHEM 125A - Freshman Organic Chemistry I
Lecture 34 - Sharpless Oxidation Catalysts and the Conformation of Cycloalkanes. Professor Barry Sharpless of Scripps describes the Nobel-prizewinning development of titanium-based catalysts for stereoselective oxidation, the mechanism of their reactions, and their use in preparing esomeprazole. Conformational energy of cyclic alkanes illustrates the use of molecular mechanics. (from oyc.yale.edu)
| Lecture 34 - Sharpless Oxidation Catalysts and the Conformation of Cycloalkanes |
| Time | Lecture Chapters |
| [00:00:00] | 1. Introduction for Professor Barry Sharpless |
| [00:02:55] | 2. The Reactivity of Allyic Alcohols and Vanadium-Catalyzed Epoxidations |
| [00:11:45] | 3. Research with Katsuki and the Discovery of Combining Titanium with Tartaric Acid |
| [00:21:11] | 4. The Mechanism for Asymmetric Epoxidation of Olefins and the Story of Nexium |
| [00:41:06] | 5. The Conformation of Rings: Carvone and Cyclohexane |
| References |
| Lecture 34 - Sharpless Oxidation Catalysts and the Conformation of Cycloalkanes Instructor: Professor J. Michael McBride. Resources: Professor McBride's website resource for CHEM 125 (Fall 2008). Transcript [html]. Audio [mp3]. Download Video [mov]. |
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