CHEM 125A - Freshman Organic Chemistry I
Lecture 29 - Preparing Single Enantiomers and the Mechanism of Optical Rotation. Within a lecture on biological resolution, the synthesis of single enantiomers, and the naming and 3D visualization of omeprazole, Professor Laurence Barron of the University of Glasgow delivers a guest lecture on the subject of how chiral molecules rotate polarized light. Mixing wave functions by coordinated application of light's perpendicular electric and magnetic fields shifts electrons along a helix that can be right- or left-handed, but so many mixings are involved, and their magnitudes are so subtle, that predicting net optical rotation in practical cases is rarely simple. (from oyc.yale.edu)
| Lecture 29 - Preparing Single Enantiomers and the Mechanism of Optical Rotation |
| Time | Lecture Chapters |
| [00:00:00] | 1. Introduction: Challenges in Isolating Enantiomers Despite Optical Activity |
| [00:06:09] | 2. Barron: A Sketch of Lord Kelvin and Chirality |
| [00:12:35] | 3. Natural and Magnetic Optical Rotation |
| [00:20:50] | 4. Understanding Optical Activity via the Carbonyl Chromophore |
| [00:37:22] | 5. Who Cares? Chiral Switches in Life and Drugs |
| References |
| Lecture 29 - Preparing Single Enantiomers and the Mechanism of Optical Rotation Instructor: Professor J. Michael McBride. Resources: Professor McBride's website resource for CHEM 125 (Fall 2008). Transcript [html]. Audio [mp3]. Download Video [mov]. |
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