CHEM 125A - Freshman Organic Chemistry I
Lecture 30 - Esomeprazole as an Example of Drug Testing and Usage. The chemical mode of action of omeprazole is expected to be insensitive to its stereochemistry, making clinical trials of the proposed virtues of a chiral switch crucial. Design of the clinical trials is discussed in the context of marketing. Otolaryngologist Dr. Dianne Duffey provides a clinician's perspective on the testing and marketing of pharmaceuticals, on the FDA approval process, on clinical trial system, on off-label uses, and on individual and institutional responsibility for evaluating pharmaceuticals. (from oyc.yale.edu)
| Lecture 30 - Esomeprazole as an Example of Drug Testing and Usage |
| Time | Lecture Chapters |
| [00:00:00] | 1. Introduction: The Chemical Properties and Reactivity of Prilosec |
| [00:06:58] | 2. The Economics of Clinical Trials |
| [00:19:57] | 3. Duffey: How Do I Know that the Drug is Effective? |
| [00:30:26] | 4. The Phases of Clinical Trials, Results for Esomeprazole and Omeprazole, ....and Off-Label Use |
| [00:42:01] | 5. Pharmaceutical Marketing Mentality and Q&A |
| References |
| Lecture 30 - Esomeprazole as an Example of Drug Testing and Usage Instructor: Professor J. Michael McBride. Resources: Professor McBride's website resource for CHEM 125 (Fall 2008). Transcript [html]. Audio [mp3]. Download Video [mov]. |
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