CHEM 125A - Freshman Organic Chemistry I
Lecture 25 - Models in 3D Space (1869-1877); Optical Isomers. Despite cautions from their conservative elders, young chemists like Paterno and van't Hoff began interpreting molecular graphs in terms of the arrangement of a molecule's atoms in 3-dimensional space. Benzene was one such case, but still more significant was the prediction, based on puzzling isomerism involving "optical activity," that molecules could be "chiral," that is, right- or left-handed. Louis Pasteur effected the first artificial separation of racemic acid into tartaric acid and its mirror-image. (from oyc.yale.edu)
| Lecture 25 - Models in 3D Space (1869-1877); Optical Isomers |
| Time | Lecture Chapters |
| [00:00:00] | 1. Venturing into 3-D Arrangements of a Molecule's Atoms |
| [00:11:41] | 2. Exchanges between van't Hoff and Ladenburg on Aromaticity and Chirality |
| [00:22:58] | 3. In-Class Observations and Experiments on Chirality |
| [00:39:14] | 4. Louis Pasteur's Artificial Separation of Racemic Acid |
| References |
| Lecture 25 - Models in 3D Space (1869-1877); Optical Isomers Instructor: Professor J. Michael McBride. Resources: Professor McBride's website resource for CHEM 125 (Fall 2008). Transcript [html]. Audio [mp3]. Download Video [mov]. |
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