7.91J Fundamentals of Computational and Systems Biology (Spring 2014, MIT OCW): Lecture 06

7.91J Fundamentals of Computational and Systems Biology

7.91J Fundamentals of Computational and Systems Biology (Spring 2014, MIT OCW). Instructors: Prof. Christopher Burge, Prof. David Gifford, and Prof. Ernest Fraenkel. This course is an introduction to computational biology emphasizing the fundamentals of nucleic acid and protein sequence and structural analysis; it also includes an introduction to the analysis of complex biological systems.

The MIT Initiative in Computational and Systems Biology is a campus-wide research and education program that links biology, engineering, and computer science in a multidisciplinary approach to the systematic analysis and modeling of complex biological phenomena. This course is one of a series of core subjects offered through the CSB Ph.D program, for students with an interest in interdisciplinary training and research in the area of computational and systems biology. (from ocw.mit.edu)

Lecture 06 - Genome Assembly

Prof. Gifford talks about two different ways to assemble a genome de novo. The first approach is overlap layout consensus assemblers, as exemplified by string graph assemblers. The second approach is de Bruijn graph-based assemblers.

Go to the Course Home or watch other lectures:

Lecture 01 - Introduction to Computational and Systems Biology

Lecture 02 - Local Alignment (BLAST) and Statistics

Lecture 03 - Global Alignment of Protein Sequences (NW, SW, PAM, BLOSUM)

Lecture 04 - Comparative Genomic Analysis of Gene Regulation

Lecture 05 - Library Complexity and Short Read Alignment (Mapping)

Lecture 06 - Genome Assembly

Lecture 07 - ChIP-seq Analysis; DNA-protein Interactions

Lecture 08 - RNA-sequence Analysis: Expression, Isoforms

Lecture 09 - Modeling and Discovery of Sequence Motifs

Lecture 10 - Markov and Hidden Markov Models of Genomic and Protein Features

Lecture 11 - RNA Secondary Structure - Biological Functions and Prediction