7.91J Fundamentals of Computational and Systems Biology
7.91J Fundamentals of Computational and Systems Biology (Spring 2014, MIT OCW). Instructors: Prof. Christopher Burge, Prof. David Gifford, and Prof. Ernest Fraenkel. This course is an introduction to computational biology emphasizing the fundamentals of nucleic acid and protein sequence and structural analysis; it also includes an introduction to the analysis of complex biological systems.
The MIT Initiative in Computational and Systems Biology is a campus-wide research and education program that links biology, engineering, and computer science in a multidisciplinary approach to the systematic analysis and modeling of complex biological phenomena. This course is one of a series of core subjects offered through the CSB Ph.D program, for students with an interest in interdisciplinary training and research in the area of computational and systems biology.
(from ocw.mit.edu)
| Lecture 04 - Comparative Genomic Analysis of Gene Regulation |
Prof. Burge discusses comparative genomics. He begins with a review of global alignment of protein sequences, then talks about Markov models, the Jukes-Cantor model, and Kimura models. He discusses types of selection: natural, negative, and positive.
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