7.81J Systems Biology (Fall 2014, MIT OCW): Lecture 17 - Fitness Landscapes and Sequence Spaces

7.81J Systems Biology

7.81J Systems Biology (Fall 2014, MIT OCW). Instructor: Professor Jeff Gore. This course provides an introduction to cellular and population-level systems biology with an emphasis on synthetic biology, modeling of genetic networks, cell-cell interactions, and evolutionary dynamics. Cellular systems include genetic switches and oscillators, network motifs, genetic network evolution, and cellular decision-making. Population-level systems include models of pattern formation, cell-cell communication, and evolutionary systems biology. (from ocw.mit.edu)

Lecture 17 - Fitness Landscapes and Sequence Spaces

In this lecture, Prof. Jeff Gore continues his discussion of clonal interference and the equivalence principle from the last lecture. He discussed clonal interference and the rate of evolution. And finally he thinks about evolution from the perspective of rugged fitness landscapes.

Go to the Course Home or watch other lectures:

Lecture 01 - Introduction to the Class and Overview of Topics

Lecture 02 - Input Function, Michaelis-Menten kinetics, and Cooperativity

Lecture 03 - Autoregulation, Feedback and Bistability

Lecture 04 - Synthetic Biology and Stability Analysis in the Toggle Switch

Lecture 05 - Oscillatory Genetic Networks

Lecture 06 - Graph Properties of Transcription Networks

Lecture 07 - Feed-forward Loop Network Motif

Lecture 08 - Introduction to Stochastic Gene Expression

Lecture 09 - Causes and Consequences of Stochastic Gene Expression

Lecture 10 - Stochastic Modeling

Lecture 11 - Life at Low Reynolds Number