Lecture 38 - Review: Synthesis of Cortisone. Discoverers of the structure and biological activity of steroid hormones won seven Nobel Prizes between 1927 and 1975. Studying the steps involved in
Woodward's 1951 "total" synthesis of cortisone provides a review of the organic reactions covered this semester. Many steps involved novel insights, others were based on lore from previous work in the area.
The overall yield of such sequential syntheses is typically much lower than that of convergent syntheses. Practical syntheses of cortisone were based on modification of related steroids readily available from nature.
Milestones in total synthesis include both purely intellectual work with natural products and commercially important synthesis of designed pharmaceuticals. The course ends with thanks to those, young and old,
who have taught us all. (from oyc.yale.edu)
Lecture 38 - Review: Synthesis of Cortisone
Time
Lecture Chapters
[00:00:00]
1. Steroids and the Medicinal Activity of Cortisone
[00:07:43]
2. Woodward's Total Synthesis of Cortisone
[00:33:27]
3. Practical Synthesis of Cortisone
[00:38:59]
4. Some Milestones in Organic Synthesis
[00:44:59]
5. Thanks to Teachers, Colleagues, Family, and Students
References
Lecture 38 - Review: Synthesis of Cortisone
Instructor: Professor J. Michael McBride. Resources: Professor McBride's website resource for CHEM 125b (Spring 2011). Transcript [html]. Audio [mp3]. Download Video [mov].