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Chemistry 125: Advanced Organic Chemistry

Chemistry 125: Advanced Organic Chemistry (Spring 2016, UC Irvine). Instructor: Professor James S. Nowick. The course builds upon the concepts and skills learned in a typical year long sophomore-level organic chemistry class. Topics include: The Chemical Literature and Databases; Stereochemistry and Structural Organic Chemistry; Synthetic Organic Chemistry; Mechanistic and Physical Organic Chemistry; NMR Spectroscopy. The course follows closely to the textbook Intermediate Organic Chemistry, 3rd edition, by Ann M. Fabirkiewicz and John C. Stowell.

Lecture 28 - 13C-NMR Spectroscopy, Introduction to 2D NMR, COSY and HMQC

Go to the Course Home or watch other lectures:

Lecture 01 - Nomenclature: Bicyclic Compounds

Lecture 02 - Spirocyclic Compounds, Polycyclic Hydrocarbons, and Heterocyclic Compounds

Lecture 03 - Databases and the Chemical Literature

Lecture 04 - Stereochemistry: Properties of Stereoisomers

Lecture 05 - Concepts in Stereochemistry

Lecture 06 - Stereoselectivity in the Aldol Reaction

Lecture 07 - Organic Reaction Mechanisms

Lecture 08 - Reaction Kinetics

Lecture 09 - Effect of Activation Energies and Temperature on Reaction Rates: The Eyring Equation

Lecture 10 - Linear Free-Energy Relationships, The Kinetic Isotope Effect

Lecture 11 - Molecular Orbitals and Aromaticity

Lecture 12 - Introduction to Pericyclic Reactions, Electrocyclic Reactions

Lecture 13 - Pericyclic Reactions: Cycloadditions and Sigmatropic Rearrangements

Lecture 14 - Functional Group Transformations: The Importance of Oxidation State

Lecture 15 - Oxidation and Reduction of Alcohols and Carbonyl Compounds

Lecture 16 - Stereoselective Reduction; Mitsunobu Reaction; Barton-McCombie Deoxygenation

Lecture 17 - Carbon-Carbon Bond Forming Reactions: The Importance of the Carbonyl Group

Lecture 18 - Claisen Condensation and Michael Addition

Lecture 19 - Acid-Catalyzed Aldol Reactions and the Mannich Reaction

Lecture 20 - Enamines, the Wittig Reaction, and Cyclopropanation

Lecture 21 - Umpolung: Benzoin Condensation, Acyl Anion Equivalents, and the Acyloin Condensation

Lecture 22 - Retrosynthetic Analysis, The Diels-Alder Reaction and the Robinson Annulation

Lecture 23 - Effects of Concentration, Stoichiometry, and Other Reaction Conditions

Lecture 24 - How Temperature and Other Conditions Affect Reactions

Lecture 25 - NMR Spectroscopy: How NMR Works, Chemical Shifts

Lecture 26 - Spin-Spin Coupling in 1H NMR Spectroscopy

Lecture 27 - Determining Stereochemistry and Regiochemistry by NMR

Lecture 28 - 13C-NMR Spectroscopy, Introduction to 2D NMR, COSY and HMQC