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7.01SC Fundamentals of Biology

7.01SC Fundamentals of Biology (Fall 2011, MIT OCW). Instructors: Prof. Eric Lander, Prof. Graham Walker, Prof. Sallie Chisholm, et al. This consists of a series of video lectures given by Prof. Eric Lander, Prof. Robert Weinberg, Prof. Tyler Jacks, et al.. This course focuses on the basic principles of biochemistry, molecular biology, genetics, and recombinant DNA. These principles are necessary to understanding the basic mechanisms of life and anchor the biological knowledge that is required to understand many of the challenges in everyday life, from human health and disease to loss of biodiversity and environmental quality. (from ocw.mit.edu)

Lecture 20 - cDNA Libraries and Expression Libraries


References
Lecture 20 - cDNA Libraries and Expression Libraries
This session will review how to make a recombinant cDNA library and how to use this library to find a specific gene. This session will outline the differences between a genomic and a cDNA library, and discuss how to use a cDNA library to clone a gene of interest.

Go to the Course Home or watch other lectures:

Biochemistry
Lecture 01 - The Nature of Evolution: Selection, Inheritance, and History
Lecture 02 - Covalent Bonds, Hydrogen Bonds
Lecture 03 - Macromolecules: Lipids, Carbohydrates, Nucleic Acid
Lecture 04 - Proteins, Levels of Structure, Non-Covalent Forces
Lecture 05 - Biochemical Reactions, Enzymes, and ATP
Lecture 06 - Glycolysis, Respiration, and Fermentation
Lecture 07 - Photosynthesis
Molecular Biology
Lecture 08 - DNA Structure and Classic Experiments
Lecture 09 - DNA Replication
Lecture 10 - Transcription and Translation
Lecture 11 - Alternative Approaches to Molecular Biology
Lecture 12 - Gene Regulation and the Lac Operon
Genetics
Lecture 13 - Mendel's Laws
Lecture 14 - Linkage and Recombination, Genetic Maps
Lecture 15 - Pedigrees; Human Genetics
Lecture 16 - Biochemical Genetics
Recombinant DNA
Lecture 17 - Development of Recombinant DNA
Lecture 18 - Basic Mechanisms of Cloning: Restriction Enzymes and Cloning Vectors
Lecture 19 - Constructing and Screening a Recombinant DNA Library
Lecture 20 - cDNA Libraries and Expression Libraries
Lecture 21 - Agarose Gel Electrophoresis, DNA Sequencing, PCR