7.016 Introductory Biology (Fall 2018, MIT OCW). Instructors: Prof. Barbara Imperiali and Prof. Adam Martin. This course provides an introduction to fundamental principles of biochemistry, molecular biology, and genetics for understanding the functions of living systems. Taught for the first time in Fall 2013, this course covers examples of the use of chemical biology and twenty-first-century molecular genetics in understanding human health and therapeutic intervention.
(from ocw.mit.edu)
Lecture 18 - SNPs and Human Genetics
Instructor: Prof. Adam Martin. Using the example of aniridia, which disrupts formation of the iris, Professor Martin describes how to clone a gene that's responsible for a disease. He covers the techniques of positional gene cloning, genomic mapping, cDNA libraries, and hybridization.